Few hundred gram to few kilo Synthesis-Non GMP
Intermediates and Building blocks Compound for Pk/PD Toxicology studies
Reactors (WFH)
- 100L (one) glass reactor with distillation RT—65 C to 170 C temperature range
- 50L (one) Glass reactor with distillation -65 C to 170 C temperature range
- 10L (one) RBF with bath -70C to 150C temperature range using dry ice and heating oil
Resources
- 1 Lead Scientist
- 2 process chemists
- PhD/MSc with experience With Kilo lab
- 2 support staff
- BSc with experience working in scale-up environment
- Fee for Service projects
Other Facilities
- Vacuum tray dryer
- Dedicated washing and storage area
- 10L pressure reactor (i.e.Hydrogenator)
- High Vac distillation High vac pump (35m3/hr)
- Lab Freeze to store intermediate
- 2. (12m3/hr) Oil free vacuum pump
Target scale is 100 g to multiple Kgs depending upon the chemistry
Kilo Lab- Capabilities
- Development of processes & synthesis of known products as per client’s requirement
- Simpler routes with efficient recovery, cost reduction for contract
- Synthesis of Chemical Entities as per customer request
- Exothermic reaction (For ex AlCl3, nitration)
- Mercapto reaction ( For ex H2S and other sulphur containing reagents)
- Reactions using hazardous reagents (For ex POCl3, SOCl2, Acetic acid)
- Cyanation reactions with agreed partner.
- To Support aliquot trouble shooting/Process optimisation reactions/Trial reactions for Scale up compounds.
- Column Chromatography,
- High vacuum (up to 1 mm) distillation
- High pressure reactions
- Mass temperature from – 65 ° C to +170° C
- Capabilities for reactions involving inert atmosphere & low temperature such
- as n-BuLi, Grignard reactions and under inert atmosphere.